منابع مشابه
Multiscale modeling of nucleosome dynamics.
Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the constituent histone tails mediate chromatin stability and regulate gene expression. For this reason, it is important to understand structural dynamics of nucleosomes at atomic levels. We report a novel multiscale model of the fundamental chromatin unit, a nucleosome, using a simplified model for rapid dis...
متن کاملDynamics of Macro–Nano Mechanical Systems; Fixed Interfacial Multiscale Method
The continuum based approaches don’t provide the correct physics in atomic scales. On the other hand, the molecular based approaches are limited by the length and simulated process time. As an attractive alternative, this paper proposes the Fixed Interfacial Multiscale Method (FIMM) for computationally and mathematically efficient modeling of solid structures. The approach is applicable to mult...
متن کاملMultiscale Modeling of RNA Structure and Dynamics
We have developed a multiscale approach for RNA folding using discrete molecular dynamics (DMD), a rapid conformational sampling algorithm. We use a coarse-grained representation to effectively model RNA structures. Benchmark studies suggest that the DMD-based RNA model is able to accurately fold small RNA molecules (<50 nucleotides). However, the large conformational space and force field inac...
متن کاملMultiscale modeling of current-driven magnetization dynamics
Understanding magnetization dynamics in magnetic materials under external current control plays a vital role in magnetic storage devices, such as magnetoresistance random access memories and race-track memories. In this presentation, we will discuss how to model such a phenomenon at different spatial and temporal scales. Consequently, a series of models is obtained with increasing accuracy. Eff...
متن کاملMultiscale modelling of nucleosome core particle aggregation.
The nucleosome core particle (NCP) is the basic building block of chromatin. Under the influence of multivalent cations, isolated mononucleosomes exhibit a rich phase behaviour forming various columnar phases with characteristic NCP-NCP stacking. NCP stacking is also a regular element of chromatin structure in vivo. Understanding the mechanism of nucleosome stacking and the conditions leading t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.094805